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Cat. No.: HY-189438

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PIP4K ligand-1

PIP4K ligand-1 is the target protein ligand for the molecular glue LRK-4189 (HY-175751) and can be used in research on microsatellite-stable colorectal cancer.

For research use only. We do not sell to patients.

Formula: C₂₁H₂₂FN₅O
Molecular Weight:379.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIP4K ligand-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

PIP4K ligand-1 is the target protein ligand for the molecular glue LRK-4189 (HY-175751) and can be used in research on microsatellite-stable colorectal cancer^[1].

IC₅₀ & Target

PIP4K2C

In Vitro

Highly selective PIP4K2γ binders demonstrate that this atypical lipid kinase is ligandable with meaningful selectivity, enabling the subsequent design of the LRK-4189 degrader^[1].
A cereblon-based heterobifunctional degrader of PIP4K2γ provides the structural basis for an evaluated targeted degrader within the PI4K family^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 379.43
Formula C₂₁H₂₂FN₅O
SMILES

N[C@H]1CC[C@@H](CC1)NC2=NC(C3=CC=CC(N4C=CC=CC4=O)=C3)=C(C=N2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun Y, et al. Nuclear phosphoinositide signaling in cell biology and disease. Developmental cell. 2026 Mar 11;61(3):473-504.

[2]. Llorente A, et al. A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks. The Journal of biological chemistry. 2026 Jun;302(6):113071.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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