Plaunotol
Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer . Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer .
For research use only. We do not sell to patients.
- CAS No.: 64218-02-6
- Formula: C20H34O2
- Molecular Weight:306.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1[2].
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1[2].
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colon cancer cell line DLD1
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Concentration:0, 10, 20, or 40 μM
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Incubation Time:24 or 48 h
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Result:Inhibited the proliferation of human colon cancer cell line DLD1 after 48 h.
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Cell Line:human colon cancer cell line DLD1
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Concentration:40 μM
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Incubation Time:24 or 48 h
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Result:Caused a significant increase in the population of Annexin V [+] apoptotic cells.
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Cell Line:human colon cancer cell line DLD1
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Concentration:40 μM
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Incubation Time:48 h
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Result:Induced PARP cleavage, and showed activation of caspase-3.
In Vivo
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 [3].
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3]
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Dosage:10, 25 or 50 mg/kg
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Administration:Oral administration
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Result:Plaunotol attenuated the severity of the gastric mucosal lesions.
- Research Protocol for Infectious Diseases
- Human pluripotent stem cell endothelial-cell differentiation
- Vascular/Branching Fractal Analysis
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Bacterial live/dead nucleic-acid viability staining
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Endothelial Tube Formation Assay
- Apoptosis Solutions
- MTT Cell Proliferation Assay
- Endothelial Cell Migration/Angiogenic Sprouting Assay
Chemical Information
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CAS No. 64218-02-6
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Molecular Weight 306.48
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Formula C20H34O2
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SMILES
C/C(C)=C\CC/C(C)=C/CC/C(CO)=C/CC/C(C)=C/CO
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Synonyms
CS-684
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[2]. Oshikawa N, et al. Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. J Surg Res. 2009 May 15;153(2):246-53. [Content Brief]
[3]. Ohta Y, et al. Plaunotol prevents the progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacology. 2005 Jul;74(4):182-92. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Plaunotol Related Classifications
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