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Polzastobart

(Synonyms: JTX-8064)
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Based on 1 Customer Validation

Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

For research use only. We do not sell to patients.

  • Purity : 97.81%
  • CAS No.: 2640981-19-5
  • Molecular Weight:146.48 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Polzastobart
  • Experimental Validation Results for Polzastobart
  • Experimental Validation Results for Polzastobart
  • Polzastobart Chemical Structure
    Polzastobart Chemical Structure
CAS No.: 2640981-19-5
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Polzastobart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Flow cytometric analysis of 1X106 THP-1 cells with Polzastobart (HY-P990061, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized LILRB2/CD85d/ILT-4 Protein, Human can bind Polzastobart. The EC50 for this effect is 8.336 ng/mL.

  • Polzastobart Chemical Structure
    1/16
  • Polzastobart
  • Flow cytometric analysis of 1X106 THP-1 cells with Polzastobart (HY-P990061, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized LILRB2/CD85d/ILT-4 Protein, Human can bind Polzastobart. The EC50 for this effect is 8.336 ng/mL.