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Cat. No.: HY-189744

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PPO-IN-28

PPO-IN-28 is a protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i of 15.6 nM against Nicotiana tabacum PPO. PPO-IN-28 binds to the PPO active site and blocks the catalytic conversion of protoporphyrinogen IX to protoporphyrin IX, leading to accumulation of protoporphyrinogen IX and reactive oxygen species-mediated membrane lipid peroxidation. PPO-IN-28 exhibits broad-spectrum post-emergence herbicidal activity against various weed species. PPO-IN-28 shows favorable crop safety in crops such as corn and wheat. PPO-IN-28 can be used in research related to plant herbicides.

For research use only. We do not sell to patients.

CAS No.: 3127787-62-3
Formula: C₂₀H₁₈ClF₄N₃O₅
Molecular Weight:491.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PPO-IN-28 Chemical Structure

CAS No.: 3127787-62-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

PPO-IN-28 (Compound C34) (0.5 nM-50 mM) is a potent NtPPO inhibitor with K_i = 15.6 nM in cell-free enzyme assays^[1].
PPO-IN-28 (9.375-150 g a.i./ha) exhibits strong post-emergence herbicidal activity against six weeds, and completely inhibits P. oleracea and A. juncea even at low concentrations^[1].
PPO-IN-28 (75-150 g a.i./ha) exhibits broad-spectrum herbicidal activity and completely inhibits 17 weed species at high concentrations^[1].
PPO-IN-28 (75-150 g a.i./ha; 25 days) has good crop safety, causing 10-20% phytotoxicity to peanuts and soybeans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 3127787-62-3
Molecular Weight 491.82
Formula C₂₀H₁₈ClF₄N₃O₅
SMILES

CC1=CC(C(F)(F)F)=NN1C2=CC(C3=NOC(C(OC(C(OC)=O)C)=O)(C)C3)=C(Cl)C=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang J, et al. Discovery of Novel N-Phenylpyrazole Derivatives as Protoporphyrinogen IX Oxidase Inhibitors[J]. Journal of Agricultural and Food Chemistry, 2026, 74(38): 29909-29919.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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