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Cat. No.: HY-134822

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PROTAC BRD4 Degrader-18

PROTAC BRD4 Degrader-18 is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-18 binds to BRD4 and recruits E3 ubiquitin ligase, inducing ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against ovarian cancer cell lines. PROTAC BRD4 Degrader-18 can be used in research related to ovarian cancer.
(Pink: BRD4 ligand (HY-78695); Blue: VHL ligand (HY-173627); Black: linker (HY-42427)).

For research use only. We do not sell to patients.

CAS No.: 1949837-13-1
Formula: C₄₉H₆₀ClN₉O₇S₂
Molecular Weight:986.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BRD4 Degrader-18 Chemical Structure

CAS No.: 1949837-13-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

PROTAC BRD4 Degrader-18 is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-18 binds to BRD4 and recruits E3 ubiquitin ligase, inducing ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against ovarian cancer cell lines. PROTAC BRD4 Degrader-18 can be used in research related to ovarian cancer^[1]. (Pink: BRD4 ligand (HY-78695); Blue: VHL ligand (HY-173627); Black: linker (HY-42427)).

IC₅₀ & Target

^[1]

BRD4

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

OthersAnti-cancer

Others

PROTAC BRD4 Degrader-18 (example 72) mediates BRD4 degradation in 22RV1 cells, with a BRD4 degradation DC₅₀ > 1000 nM and a maximum inhibitory activity of 10.2 %^[1].

Anti-cancer

PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against A2780 and COV434 ovarian cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 1949837-13-1
Molecular Weight 986.64
Formula C₄₉H₆₀ClN₉O₇S₂
SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C[C@@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C7=NN=C(C)N27
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qian Y M, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO patent, WO2017030814A1. 2017.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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