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Cat. No.: HY-186312

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PROTAC IRF5 degrader-2

PROTAC IRF5 degrader-2 (I-7) is a bifunctional IRF5 PROTAC degrader. PROTAC IRF5 degrader-2 recruits IRF5 to the E3 ubiquitin ligase for targeted degradation. PROTAC IRF5 degrader-2 is applicable to the research of autoimmune diseases.

For research use only. We do not sell to patients.

Formula: C₄₇H₅₁F₄N₉O₄
Molecular Weight:881.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC IRF5 degrader-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]

IRF5

All PROTACs Isoforms :

In Vitro

IRF5 is a transcription factor of the IRF family, which mainly mediates innate immune responses downstream of pattern recognition receptors such as TLR, drives the production of pro-inflammatory cytokines and type I interferons, and regulates the polarization of macrophages toward the M1 pro-inflammatory phenotype. Its abnormal activation is closely associated with autoimmune diseases such as lupus erythematosus.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 881.96
Formula C₄₇H₅₁F₄N₉O₄
SMILES

FC1(CCC(CN2C=NC(C3=NC(OC4=CC=CC5=C4NC(N5C)=O)=CC(C6CCC(N7CCC(C8=CC=C9C(N(C)N=C9C%10CCC(NC%10=O)=O)=C8)C(C7)(F)F)CC6)=C3)=C2)CC1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. ZHANG, Yi, et al. IRF5 DEGRADERS AND USES THEREOF. WO2026156070A1. 2026.07.23.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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