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Cat. No.: HY-188209

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PROTAC IRF5 degrader-3

PROTAC IRF5 degrader-3 (Compound I-300) is a PROTAC degrader targeting interferon regulatory factor 5 (IRF5), with a DC₅₀ of 1-10 nM. PROTAC IRF5 degrader-3 can be used in research on IRF5-associated autoimmune and inflammatory diseases, such as systemic lupus erythematosus and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 3137885-65-2
Formula: C₄₈H₅₃F₄N₉O₄
Molecular Weight:895.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC IRF5 degrader-3 Chemical Structure

CAS No.: 3137885-65-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

IRF5

1-10 nM (DC₅₀)

All PROTACs Isoforms :

Chemical Information

CAS No. 3137885-65-2
Molecular Weight 895.99
Formula C₄₈H₅₃F₄N₉O₄
SMILES

CN1C2=CC(C3C(F)(CN([C@@H]4CC[C@@H](C5=CC(OC6=C7C(N(C(N7)=O)C)=CC=C6)=NC(C8=CN(C=N8)[C@H](C9CCC(F)(CC9)F)C)=C5)CC4)CC3)F)=CC=C2C(C%10C(NC(CC%10)=O)=O)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. IRF5 degraders and uses thereof. World Intellectual Property Organization. WO 2026/156070 A1. 2026-07-23.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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