PROTAC K-Ras Degrader-2 formic
PROTAC K-Ras Degrader-2 formic (compound 48) is a KRAS G12V PROTAC degrader with an IC50 of 20-200 nM for KRAS G12V/RAF1. PROTAC K-Ras Degrader-2 formic degrades SW620 KRAS G12V with a DC50 of 1-10 nM. PROTAC K-Ras Degrader-2 formic inhibits cell growth of SW620 3D cell with an IC50 of ≤10 nM. PROTAC K-Ras Degrader-2 formic can be used for the study of colorectal cancer (CRC).
(Pink: KRas G12V Target protein ligand; Blue: E3 ligase ligand; Black: linker).
For research use only. We do not sell to patients.
- Formula: C53H62F4N8O7
- Molecular Weight:999.10
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
KRAS G12V/RAF1 20-200 nM (IC50) |
KRas G12V 1-10 nM (DC50) |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 999.10
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Formula C53H62F4N8O7
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SMILES
OC=O.FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OCC6(CC6)CN7CCC(C)(CC7)CN8CCN(C9=CC(F)=C(C%10C(NC(CC%10)=O)=O)C(F)=C9)CC8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (100.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0009 mL | 5.0045 mL | 10.0090 mL | 25.0225 mL |
| 5 mM | 0.2002 mL | 1.0009 mL | 2.0018 mL | 5.0045 mL | |
| 10 mM | 0.1001 mL | 0.5005 mL | 1.0009 mL | 2.5023 mL | |
| 15 mM | 0.0667 mL | 0.3336 mL | 0.6673 mL | 1.6682 mL | |
| 20 mM | 0.0500 mL | 0.2502 mL | 0.5005 mL | 1.2511 mL | |
| 25 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0009 mL | |
| 30 mM | 0.0334 mL | 0.1668 mL | 0.3336 mL | 0.8341 mL | |
| 40 mM | 0.0250 mL | 0.1251 mL | 0.2502 mL | 0.6256 mL | |
| 50 mM | 0.0200 mL | 0.1001 mL | 0.2002 mL | 0.5005 mL | |
| 60 mM | 0.0167 mL | 0.0834 mL | 0.1668 mL | 0.4170 mL | |
| 80 mM | 0.0125 mL | 0.0626 mL | 0.1251 mL | 0.3128 mL | |
| 100 mM | 0.0100 mL | 0.0500 mL | 0.1001 mL | 0.2502 mL |
PROTAC K-Ras Degrader-2 formic Related Classifications
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