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Cat. No.: HY-181834

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PROTAC MLLT1 Degrader-1

Name: PROTAC MLLT1 Degrader-1
Brand: MedChemExpress
SKU: HY-181834
Price: 700.00 USD
Availability: InStock
Rating: 5 (1 reviews)

PROTAC MLLT1 Degrader-1 is a PROTAC degrader targeting MLLT1. PROTAC MLLT1 Degrader-1 inhibits AML cell proliferation and viability, suppresses tumor growth in human AML xenograft models, and can block the oncogene transcriptional program. PROTAC MLLT1 Degrader-1 can be used for the research of MLL-rearranged acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

CAS No.: 3111054-37-3
Formula: C₃₈H₃₈N₆O₄
Molecular Weight:642.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC MLLT1 Degrader-1 Chemical Structure

CAS No.: 3111054-37-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTAC MLLT1 Degrader-1 (example 8) (0.01-1 μM) induces ≥ 75% MLLT1 protein degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PROTAC MLLT1 Degrader-1 (example 8) exerts anti-tumor effects in human MLL-rearranged acute myeloid leukemia (AML) xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3111054-37-3
Molecular Weight 642.75
Formula C₃₈H₃₈N₆O₄
SMILES

O=C(CC1)NC(C1N(C2=O)CC3=C2C=CC=C3C#CCCCCC4=CC=C(C(NC5=NC=C6C=C([C@@H]7N(C)CCC7)NC6=C5)=O)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renner AC, et al. Modulation of Cancer Networks through Protein Degradation, DNA Repair Inhibition, and Quantitative Interactomics. ACS Med Chem Lett. 2026;17(3):628-630. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PROTAC MLLT1 Degrader-1

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms