Endothelin R Type B (EDNRB)
Endothelin receptor type B (EDNRB, ETB) is a Gq/Gi-coupled receptor that binds all three endothelins with similar affinity and is expressed mainly on vascular endothelium, where its activation releases nitric oxide and prostacyclin to counterbalance ETA-mediated constriction, and clears circulating endothelin-1. ETB signaling is also essential during development for the migration of neural crest-derived melanocytes and enteric neurons: loss-of-function EDNRB mutations cause Waardenburg syndrome type 4 and Hirschsprung disease. In pathology, ETB is upregulated in pulmonary hypertension and melanoma. Recombinant EDNRB supports ligand-binding studies and screening of subtype-selective endothelin antagonists.
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Endothelin R Type B (EDNRB) Recombinant Proteins (4)
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Inhibitors & Agonists (42)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
