Intercellular Adhesion Molecule 5 (ICAM-5)
ICAM-5, also called telencephalin, is the neuron-specific member of the ICAM family and its largest, carrying nine Ig-like domains. It is expressed exclusively in the mammalian telencephalon, where it localizes to somatodendritic membranes and regulates dendritic spine maturation, spine morphology and excitatory synapse formation through homophilic adhesion and heterophilic binding to LFA-1 on T cells and to beta-1 integrins. Neuronal activity and metalloproteinases release soluble ICAM-5, and elevated soluble telencephalin in cerebrospinal fluid has been reported in encephalitis and other inflammatory brain conditions, positioning it as a candidate neurological biomarker. Recombinant ICAM-5 supports studies of synapse development and neuroimmune adhesion.
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Intercellular Adhesion Molecule 5 (ICAM-5) Recombinant Proteins (4)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
