Pigment Epithelium Derived Factor
Pigment epithelium-derived factor (PEDF, Serpin F1) is a secreted non-inhibitory serpin first purified from retinal pigment epithelium conditioned medium. It combines potent neurotrophic and neuroprotective activities with some of the strongest anti-angiogenic effects known in the body, blocking endothelial proliferation and new-vessel growth. PEDF binds collagen and glycosaminoglycans in the extracellular matrix, is highly expressed in eye, liver and brain, and circulates in plasma. Its actions are mediated through surface interactions including the lipase PEDF-R (PNPLA2) and laminin receptor binding, influencing neuronal survival, stem cell maintenance and tumor angiogenesis. Low PEDF levels accompany diabetic retinopathy and age-related macular degeneration, making it a therapeutic candidate.
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Pigment Epithelium Derived Factor Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
