Serpin B6
Also designated proteinase inhibitor 6 (PI6), Serpin B6 is an intracellular member of the clade B serpin family expressed in most tissues, with particularly high levels in endocrine pancreas, placenta and immune cells. Its best-characterized target is the neutrophil granule protease cathepsin G, and by neutralizing proteases that leak into the cytoplasm during inflammation it protects cells from protease-driven apoptosis. Unlike secreted serpins, PI6 acts inside the cell, buffering granzyme-type and lysosomal proteolytic insults. Altered expression has been reported in tumors and in islet-related disease contexts, making it a subject of oncology and diabetes research. Recombinant Serpin B6 supports mechanistic studies of intracellular protease control.
-
Serpin B6 Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
