Ubiquitin Conjugating Enzyme E2 V2
Encoded by the UBE2V2 gene and also known as Croc or UEV-2, this protein is the second human ubiquitin-conjugating enzyme variant (UEV). Like UEV1A, it lacks the active-site cysteine and cannot form ubiquitin thioesters; it functions instead by binding UBE2N (UBC13) as a non-catalytic partner, orienting the E2-ubiquitin intermediate so that K63-linked chains are assembled. UBE2V2/UBC13 complexes support NF-κB activation downstream of immune receptors and participate in DNA damage tolerance. UBE2V2 is broadly expressed across tissues and its complex with UBC13 is among the best-characterized K63 chain-forming machines. Recombinant UBE2V2 is used interchangeably with UEV1A to produce K63-linked polyubiquitin in vitro.
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Ubiquitin Conjugating Enzyme E2 V2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
