Ubiquitin-Specific Protease 10
USP10 is a predominantly cytoplasmic deubiquitinase best known for deubiquitinating and stabilizing p53; in response to genotoxic stress, USP10 counteracts MDM2-mediated ubiquitination and promotes p53 accumulation. The enzyme also processes other targets, including the cystic fibrosis transmembrane conductance regulator (CFTR), and supports protein trafficking at endosomes. Through its interaction with G3BP1, USP10 additionally participates in stress granule dynamics. USP10 activity is attenuated in certain tumors with wild-type p53, while its expression supports tumor cell survival in others, presenting context-dependent biology. Its G3BP1-binding motif and catalytic core have both been explored as starting points for inhibitor discovery.
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Ubiquitin-Specific Protease 10 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
