PS21M
PS21M is a negative control PROTAC degrader derived from CPS-021, as well as an inhibitor of ternary complex formation. PS21M attenuates the interaction with Cereblon ligase, restricting the formation of the PAK4-PROTAC-Cereblon ternary complex and the subsequent degradation of PAK4. PS21M serves as a negative control molecule to verify the degradation mechanism of CPS-021.
(Pink: PAK4 ligand (HY-174822); Blue: Cereblon ligand (HY-W586822); Black: linker).
For research use only. We do not sell to patients.
- Formula: C53H65N11O7
- Molecular Weight:968.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 human breast cancer cells
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Concentration:2, 5 μM
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Incubation Time:4 h
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Result:Attenuated CPS-021-induced PAK4 degradation, resulting in a PAK4 relative abundance of 1.13 versus the untreated control (set at 1.00).
Chemical Information
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Molecular Weight 968.15
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Formula C53H65N11O7
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SMILES
O=C(C1=CN(C2=NC(N)=NC=C2)C3=C1C=CC(C#CC4(O)CCCCC4)=C3)N5CCN(CC5)CCCCCCCC(N6CCN(CCNC7=CC=CC(C(N8C9CCC(N(C)C9=O)=O)=O)=C7C8=O)CC6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PS21M Related Classifications
HY-174248 Related Classifications
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