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Cat. No.: HY-159920

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PSB-22269

PSB-22269 is a competitive GPR17 antagonist. PSB-22269 can be used in research on multiple sclerosis.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₁NO₆
Molecular Weight:443.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PSB-22269 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PSB-22269 is a competitive GPR17 antagonist. PSB-22269 can be used in research on multiple sclerosis^[1]^[2]^[3].

In Vitro

PSB-22269 (1 h at room temperature) binds GPR17 in CHO-FITR-hGPR17 membrane radioligand binding assays with pK_i 8.05 (K_i 8.91 nM)^[1].
PSB-22269 (30 min) inhibits GPR17-induced calcium mobilization in CHO-FITR-hGPR17 cells with pIC₅₀ 7.0^[1].
PSB-22269 (0-1000 nM; 30 min) competitively inhibits GPR17-mediated calcium mobilization in 1321N1 astrocytoma cells with pIC₅₀ 6.90 and pK_B 7.46^[1].
PSB-22269 (20 min) inhibits GPR17 agonist-induced Gα_i2 activation in HEK293 cells with pIC₅₀ 6.31^[1].
PSB-22269 binds hGPR17 in the cell-free [³H]PSB-12150 binding assay using CHO-FITR cell membranes, with the reported overall IC₅₀ range of 0.0089-0.13 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 443.45
Formula C₂₆H₂₁NO₆
SMILES

COC1=CC(C(O)=O)=C(NC(C2=CC=C(C3=C(C4=CC=CC(OC)=C4)C=CC=C3)O2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Boshta NM, et al. Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17. Journal of medicinal chemistry. 2024 Nov 14;67(21):19365-19394. [Content Brief]

[2]. Lewash M, et al. GPR17 - orphan G protein-coupled receptor with therapeutic potential. Trends in pharmacological sciences. 2025 Jul;46(7):610-628.

[3]. Lewash M. Ligand binding, activation, and stabilization of the orphan G protein-coupled receptor GPR17[D]. Universitäts-und Landesbibliothek Bonn, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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