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Cat. No.: HY-187095

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PTAD-ergosta-3-one

PTAD-ergosta-3-one is a snake venom enzyme inhibitor. PTAD-ergosta-3-one inhibits the procoagulant activity of citrated plasma mediated by serine protease (SVSP) from Bothrops asper venom. PTAD-ergosta-3-one inhibits the esterase activity of PLA2 from Bothrops asper venom. PTAD-ergosta-3-one can be used in the research of snakebite envenoming.

For research use only. We do not sell to patients.

Formula: C₃₇H₅₁N₃O₃
Molecular Weight:585.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PTAD-ergosta-3-one Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

PLA2

All Phospholipase Isoforms :

In Vitro

PTAD-ergosta-3-one (62.5-500 μM; 30 min) potently and dose-dependently inhibits the procoagulant activity of citrated plasma mediated by serine proteases from Bothrops asper venom (SVSP). Its activity reaches the peak at the concentration of 500 μM, prolonging the clotting time to 300 s^[1].
PTAD-ergosta-3-one (62.5-500 μM; 30 min) weakly inhibits the amide hydrolysis activity mediated by Bothrops asper snake venom SVSP in vitro, and exhibits concentration-dependent variable effects within the tested concentration range^[1].
PTAD-ergosta-3-one (250-500 μM; 30 min) inhibits the 4-NOBA monodisperse substrate-mediated esterase activity of Bothrops asper snake venom PLA₂ in vitro at concentrations of 250 μM and 500 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 585.82
Formula C₃₇H₅₁N₃O₃
SMILES

[H][C@]12CC[C@]3(C)[C@@H]([C@@H](CC[C@@H](C)C(C)C)C)CC[C@@]3(C)[C@@]14C=C[C@]5(CC(CC[C@@]52C)=O)N6C(N(C7=CC=CC=C7)C(N64)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bacho M, et al. Targeting Bothrops asper venom enzymes: Steroidal derivatives as potential inhibitors of phospholipase A and serine proteinases. Bioorganic chemistry. 2026 Sep 15;180:110138. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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