Transglutaminase function in epidermis

  • J Invest Dermatol. 2005 Mar;124(3):481-92. doi: 10.1111/j.0022-202X.2005.23627.x.
Richard L Eckert  1 ,  Michael T Sturniolo ,  Ann-Marie Broome ,  Monica Ruse ,  Ellen A Rorke
Affiliations
  • 1. Department of Physiology and Biophysics, Case School of Medicine, Cleveland, Ohio 44106, USA. [email protected]
PMID: 15737187 DOI: 10.1111/j.0022-202X.2005.23627.x
Abstract

Surface epithelial cells, such as the epidermal keratinocyte, undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium. This epithelium functions to protect the organism from the environment. Transglutaminases, Enzymes that catalyze the formation of isopeptide protein-protein cross-links, are key Enzymes involved in the construction of this structure. This brief review will focus on the role of these Enzymes in constructing the epidermal surface.