IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding

  • Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5. doi: 10.1016/j.bmcl.2008.04.039.
George M Buckley  1 ,  Thomas A Ceska ,  Joanne L Fraser ,  Lewis Gowers ,  Colin R Groom ,  Alicia Perez Higueruelo ,  Kerry Jenkins ,  Stephen R Mack ,  Trevor Morgan ,  David M Parry ,  William R Pitt ,  Oliver Rausch ,  Marianna D Richard ,  Verity Sabin
Affiliations
  • 1. UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
PMID: 18482836 DOI: 10.1016/j.bmcl.2008.04.039
Abstract

A potent IRAK-4 inhibitor was identified through routine project cross screening. The binding mode was inferred using a combination of in silico docking into an IRAK-4 homology model, surrogate crystal structure analysis and chemical analogue SAR.

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