Propindilactones E-J, Schiartane Nortriterpenoids from Schisandra propinqua var. propinqua

  • J Nat Prod. 2008 Jul;71(7):1228-32. doi: 10.1021/np8001699.
Chun Lei  1 ,  Sheng-Xiong Huang ,  Ji-Jun Chen ,  Li-Bin Yang ,  Wei-Lie Xiao ,  Yin Chang ,  Yang Lu ,  Hao Huang ,  Jian-Xin Pu ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 18578539 DOI: 10.1021/np8001699
Abstract

Six new nortriterpenoids, propindilatones E-J (1-6), and two known (7, 8) schiartane-type nortriterpenoids were isolated from the stems of Schisandra propinqua var. propinqua. Their structures were elucidated by extensive spectroscopic analyses, and the structure of compound 4 was confirmed through single-crystal X-ray diffraction. The absolute configuration of compounds 1-3 was established using CD methods. Compounds 4-6 were noncytotoxic against K562, A549, and HT-29 human Cancer cells.