Morpholine containing CB2 selective agonists

  • Bioorg Med Chem Lett. 2009 Mar 15;19(6):1604-9. doi: 10.1016/j.bmcl.2009.02.033.
Renée Zindell  1 ,  Doris Riether ,  Todd Bosanac ,  Angela Berry ,  Mark J Gemkow ,  Andreas Ebneth ,  Sabine Löbbe ,  Ernest L Raymond ,  Diane Thome ,  Daw-Tsun Shih ,  David Thomson
Affiliations
  • 1. Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, USA.
PMID: 19243942 DOI: 10.1016/j.bmcl.2009.02.033
Abstract

Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.