Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases

  • Bioorg Med Chem. 2010 Jan 1;18(1):433-54. doi: 10.1016/j.bmc.2009.10.036.
Igor Beseda  1 ,  Laszlo Czollner ,  Priti S Shah ,  Rupesh Khunt ,  Rawindra Gaware ,  Paul Kosma ,  Christian Stanetty ,  Maria Carmen Del Ruiz-Ruiz ,  Hassan Amer ,  Kurt Mereiter ,  Thierry Da Cunha ,  Alex Odermatt ,  Dirk Classen-Houben ,  Ulrich Jordis
Affiliations
  • 1. Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria.
PMID: 19914836 DOI: 10.1016/j.bmc.2009.10.036
Abstract

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.

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