1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

  • Bioorg Med Chem Lett. 2010 May 15;20(10):3120-4. doi: 10.1016/j.bmcl.2010.03.111.
Michael B Tollefson  1 ,  Brad A Acker ,  E J Jacobsen ,  Robert O Hughes ,  John K Walker ,  David N A Fox ,  Michael J Palmer ,  Sandra K Freeman ,  Ying Yu ,  Brian R Bond
Affiliations
  • 1. Pfizer Global Research and Development, Chesterfield, MO 63017, United States. [email protected]
PMID: 20443228 DOI: 10.1016/j.bmcl.2010.03.111
Abstract

1H-Pyrazolo[4,3-d]pyrimidines are a class of potent and selective second generation phosphodiesterase 5 (PDE5) inhibitors. This work explores the potency, selectivity and efficacy of 1-(2-ethoxyethyl)-1H-pyrazolo[4,5-d]pyrimidines as PDE5 inhibitors resulting in the advancement of a clinical candidate.

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