Terpenoids and norlignans from Metasequoia glyptostroboides

  • J Nat Prod. 2011 Feb 25;74(2):234-9. doi: 10.1021/np100694k.
Liao-Bin Dong  1 ,  Juan He ,  Yuan-Yuan Wang ,  Xing-De Wu ,  Xu Deng ,  Zheng-Hong Pan ,  Gang Xu ,  Li-Yan Peng ,  Yu Zhao ,  Yan Li ,  Xun Gong ,  Qin-Shi Zhao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People's Republic of China.
PMID: 21226514 DOI: 10.1021/np100694k
Abstract

Four new Terpenoids, metaseglyptorin A (1), metasequoic acid C (2), 12α-hydroxy-8,15-isopimaradien-18-oic acid (3), and (-)-acora-2,4(14),8-trien-15-oic acid (4), and three new norlignans, metasequirins D-F (5-7), were isolated from Metasequoia glyptostroboides, together with 15 known compounds. Structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration of 7 was established by the modified Mosher method. All of the compounds were evaluated for cytotoxicity against five human tumor cell lines.