Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii

  • J Nat Prod. 2011 Sep 23;74(9):1875-80. doi: 10.1021/np200279r.
Yun-Ting Huang  1 ,  Hsun-Shuo Chang ,  Guei-Jane Wang ,  Ming-Jen Cheng ,  Chu-Huang Chen ,  Yi-Jen Yang ,  Ih-Sheng Chen
Affiliations
  • 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
PMID: 21846089 DOI: 10.1021/np200279r
Abstract

Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new Lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.