Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

Esther C Y Woon  ¹ ,  Anthony Tumber ,  Akane Kawamura ,  Lars Hillringhaus ,  Wei Ge ,  Nathan R Rose ,  Jerome H Y Ma ,  Mun Chiang Chan ,  Louise J Walport ,  Ka Hing Che ,  Stanley S Ng ,  Brian D Marsden ,  Udo Oppermann ,  Michael A McDonough ,  Christopher J Schofield