Protein engineering of penicillin acylase

  • Acta Naturae. 2010 Jul;2(3):47-61.
V I Tishkov  1 ,  S S Savin ,  A S Yasnaya
Affiliations
  • 1. Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University.
PMID: 22649651
Abstract

Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam Antibiotics and chiral compounds. In this review, the latest achievements in the production of Recombinant enzymes are discussed, as well as the results of PA type G protein engineering.

Keywords
E.coli; expression; penicillin acylase; protein engineering; structure.
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