Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens

  • J Nat Prod. 2013 Sep 27;76(9):1612-8. doi: 10.1021/np400287r.
Xia Liu  1 ,  Xing-Wei Yang ,  Chao-Qun Chen ,  Chun-Yan Wu ,  Jing-Jing Zhang ,  Jun-Zeng Ma ,  Huan Wang ,  Li-Xin Yang ,  Gang Xu
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
PMID: 23957453 DOI: 10.1021/np400287r
Abstract

Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC₅₀ 5.8-17.9 μM) against the tested tumor cell lines.