Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice

  • J Oleo Sci. 2015;64(7):737-42. doi: 10.5650/jos.ess15005.
Katsuhito Arai  1 ,  Yu Mizobuchi ,  Yoshihiko Tokuji ,  Kazuhiko Aida ,  Shinji Yamashita ,  Masao Ohnishi ,  Mikio Kinoshita
Affiliations
  • 1. Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine.
PMID: 26136173 DOI: 10.5650/jos.ess15005
Abstract

The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.

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