Biosynthesis of napyradiomycins

  • J Antibiot (Tokyo). 1987 Dec;40(12):1740-5. doi: 10.7164/antibiotics.40.1740.
K Shiomi  1 ,  H Iinuma ,  H Naganawa ,  K Isshiki ,  T Takeuchi ,  H Umezawa
Affiliations
  • 1. Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 3429338 DOI: 10.7164/antibiotics.40.1740
Abstract

Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.

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