Homologous cell membrane-based hydrogel creates spatiotemporal niches to improve outcomes of dysregulated chronic wound healing

  • Mater Today Bio. 2024 Sep 14:28:101243. doi: 10.1016/j.mtbio.2024.101243.
Yijuan Ding  1 ,  Qi Jia  1 ,  Ziwen Su  1 ,  Heying Chen  1 ,  Jialing Ye  1 ,  Dafeng Xie  1 ,  Yubo Wu  1 ,  Haiyan He  1 ,  Yanlin Peng  1 ,  Yilu Ni  1
Affiliations
  • 1. The M.O.E. Key Laboratory of Laboratory Medical Diagnostics, The College of Laboratory Medicine, Chongqing Medical University, #1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.
PMID: 39315394 DOI: 10.1016/j.mtbio.2024.101243
Abstract

The (M2M + TGF-β)@HAMA hydrogel dressing improves the outcomes of dysregulated chronic wound healing by protecting the open wound from repeated Bacterial infections, reprogramming endogenous monocytes and M1 Macrophages into an M2-phenotype, as well as enhancing fibroblastic proliferation and migration for matrix remodeling and granulation tissue formation.Image 1.

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