A new neuronal cell protecting substance, lavanduquinocin, produced by Streptomyces viridochromogenes

  • J Antibiot (Tokyo). 1995 Jul;48(7):574-8. doi: 10.7164/antibiotics.48.574.
K Shin-Ya  1 ,  S Shimizu ,  T Kunigami ,  K Furihata ,  K Furihata ,  H Seto
Affiliations
  • 1. Institute of Cellular and Molecular Biosciences, University of Tokyo, Japan.
PMID: 7649853 DOI: 10.7164/antibiotics.48.574
Abstract

A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC50 value 15.5 nm.

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