A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

  • Nature. 1994 Dec 22-29;372(6508):739-46. doi: 10.1038/372739a0.
J C Lee  1 ,  J T Laydon ,  P C McDonnell ,  T F Gallagher ,  S Kumar ,  D Green ,  D McNulty ,  M J Blumenthal ,  J R Heys ,  S W Landvatter ,  J E Strickler ,  M M McLaughlin ,  I R Siemens ,  S M Fisher ,  G P Livi ,  J R White ,  J L Adams ,  P R Young
Affiliations
  • 1. Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.
PMID: 7997261 DOI: 10.1038/372739a0
Abstract

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.

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