Identification of a major co-receptor for primary isolates of HIV-1

  • Nature. 1996 Jun 20;381(6584):661-6. doi: 10.1038/381661a0.
H Deng  1 ,  R Liu ,  W Ellmeier ,  S Choe ,  D Unutmaz ,  M Burkhart ,  P Di Marzio ,  S Marmon ,  R E Sutton ,  C M Hill ,  C B Davis ,  S C Peiper ,  T J Schall ,  D R Littman ,  N R Landau
Affiliations
  • 1. Skirball Institute for BioMolecular Medicine, New York University Medical Center, 10016, USA.
PMID: 8649511 DOI: 10.1038/381661a0
Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for Infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.