Pyrantel-d10 pamoate
Pyrantel-d10 pamoate (Pyrantel embonate-d10) is the deuterated-labeled Pyrantel pamoate (HY-12640). Pyrantel pamoate is an orally active antiparasitic agent. Pyrantel pamoate induces spastic paralysis in parasites via actions on neural and muscular cholinergic receptors as a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel pamoate eliminates both immature and mature endoparasites in horses. Pyrantel pamoate can be used in research related to parasitic infections.
For research use only. We do not sell to patients.
- Formula: C34H20D10N2O6S
- Molecular Weight:604.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 22204-24-6
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Molecular Weight 604.74
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Formula C34H20D10N2O6S
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SMILES
O=C(C1=C(O)C(CC2=C3C([2H])=C([2H])C([2H])=C([2H])C3=C([2H])C(C(O)=O)=C2O)=C4C([2H])=C([2H])C([2H])=C([2H])C4=C1[2H])O.CN5CCCN=C5/C=C/C6=CC=CS6
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Synonyms
Pyrantel embonate-d10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Tritten L, et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS neglected tropical diseases. 2011 Dec;5(12):e1457. [Content Brief]
[2]. Martin RJ, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. International journal for parasitology. 2004 Aug;34(9):1083-90. [Content Brief]
[3]. Lyons ET, et al. Critical test of three salts of pyrantel against internal parasites of the horse. Am J Vet Res. 1974 Dec;35(12):1515-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pyrantel-d10 pamoate Related Classifications
HY-12640S Related Classifications
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Keywords
- Pyrantel-d10
- Pyrantel embonate-d10
- Isotope-Labeled Compounds
- Parasite
- nAChR
- Parascaris equorum
- equine internal parasites
- small strongyles
- L-subtype cholinergic receptors
- nematodes
- intestinal nematode infections
- equine internal parasitic infections
- Draschia megastoma
- Ascaris suum
- Strongylus vulgaris
- Inhibitor
- inhibitor
- inhibit