(R,R)-Benazepril
(R,R)-Benazepril is the R configuration of Benazepril (HY-B0093). Benazepril (CGS14824A free base) is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces the production of angiotensin II. Benazepril inhibits oxidative stress and suppresses apoptosis through the PI3K/Akt signaling pathway. Benazepril effectively ameliorates diabetic nephropathy and reduces proteinuria. Benazepril is used in the study of hypertension, heart failure, and diabetic nephropathy.
For research use only. We do not sell to patients.
- CAS No.: 131064-75-0
- Formula: C24H28N2O5
- Molecular Weight:424.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 131064-75-0
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Molecular Weight 424.50
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Formula C24H28N2O5
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SMILES
C(C(O)=O)N1C=2C(CC[C@@H](N[C@H](CCC3=CC=CC=C3)C(OCC)=O)C1=O)=CC=CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hou FF, et al. Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40. [Content Brief]
[2]. Huang XM, et al. Effects of chronotherapy of benazepril on the diurnal profile of RAAS and clock genes in the kidney of 5/6 nephrectomy rats. J Huazhong Univ Sci Technolog Med Sci. 2013 Jun;33(3):368-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R,R)-Benazepril Related Classifications
HY-W742083 Related Classifications
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