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Cat. No.: HY-145603AS

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(R)-Vanzacaftor-d₄

Name: (R)-Vanzacaftor-d4
Brand: MedChemExpress
SKU: HY-145603AS
Price: 616.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: (R)-VX-121-d₄)

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(R)-Vanzacaftor-d₄ ((R)-VX-121-d₄) is the deuterated-labeled (R)-Vanzacaftor (HY-145603A). (R)-Vanzacaftor ((R)-VX-121) is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator with max activity of 30-60% and EC₅₀ of <1 μM in enteroid cells. (R)-Vanzacaftor can be used for the research of cystic fibrosis.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₅D₄N₇O₄S
Molecular Weight:621.79

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

(R)-Vanzacaftor-d₄ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 2374124-48-6
Appearance Solid
Molecular Weight 621.79
Formula C₃₂H₃₅D₄N₇O₄S
Color White to off-white
SMILES

CC1(C[C@]([H])(C([2H])([2H])N1C2=NC(N3C=CC(OC([2H])(CC4C5(C46CC6)CC5)[2H])=N3)=CC=C27)CCC/N=C8NC(S(=O)(NC7=O)=O)=CC=C\8)C
Synonyms

(R)-VX-121-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)