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Cat. No.: HY-181499

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RA190-PEG1-NH2

RA190-PEG1-NH2 (Compound S16) is a derivative of RA190 (HY-100739) and acts as a Proteasome ligand. RA190-PEG1-NH2 can be used for the synthesis of the FKBP12 PROTAC degrader RAFKBP12 (HY-181498).

For research use only. We do not sell to patients.

CAS No.: 3132225-37-4
Formula: C₃₂H₃₁Cl₄N₃O₃
Molecular Weight:647.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

RA190-PEG1-NH2 Chemical Structure

CAS No.: 3132225-37-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

Rpn13

All Ligands for E3 Ligase Isoforms :

In Vitro

Proteasome ligands are recruiting ligand components for protein degradation tools such as PROTAC, which can bind to E3 ligase and mediate the ubiquitination and degradation of target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3132225-37-4
Molecular Weight 647.42
Formula C₃₂H₃₁Cl₄N₃O₃
SMILES

NCCOCCN[C@H](C(N1C/C(C(/C(C1)=C/C2=CC(Cl)=C(Cl)C=C2)=O)=C\C3=CC=C(Cl)C(Cl)=C3)=O)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song C, et al. Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation. Angew Chem Int Ed Engl. 2026;65(9):e20039. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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RA190-PEG1-NH2

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RA190-PEG1-NH2 Related Classifications

HY-181499 Related Classifications

Bioz

Keywords

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