(Rac)-DIOA
(Rac)-DIOA ((Rac)-[(Dihydroindenyl) oxy]acetic acid) is the racemate of DIOA (HY-137148), which inhibits acid-sensitive outwardly rectifying (ASOR) and volume-sensitive outwardly rectifying (VSOR) anion channel currents, and classically inhibits K+-Cl- cotransporters (KCC). (Rac)-DIOA can be used to study mechanisms related to ischemic cerebrovascular disease, neurological diseases, tumor acidosis microenvironment, and cell volume disorders.
For research use only. We do not sell to patients.
- CAS No.: 81166-34-9
- Formula: C20H24Cl2O4
- Molecular Weight:399.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 81166-34-9
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Molecular Weight 399.31
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Formula C20H24Cl2O4
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SMILES
O=C(COC1=C(Cl)C(Cl)=C(C(C(CCCC)(C2CCCC2)C3)=O)C3=C1)O
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Synonyms
(Rac)-[(Dihydroindenyl)oxy]acetic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sato-Numata K, et al. Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel. Pflugers Archiv : European journal of physiology. 2016 May;468(5):795-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-DIOA Related Classifications
HY-137148A Related Classifications
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