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Cat. No.: HY-111197A

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(Rac)-LY-2300559

(Rac)-LY-2300559 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGlu2) and an antagonist of cysteinyl leukotriene 1 (CysLT1) receptor, with both EC₅₀ and IC₅₀ values less than 12.5 μM. (Rac)-LY-2300559 enhances glutamate-induced mGlu2 receptor signaling while exerting antagonistic activity against the CysLT1 receptor. (Rac)-LY-2300559 can be used in migraine-related research.

For research use only. We do not sell to patients.

CAS No.: 889115-58-6
Formula: C₂₆H₂₆O₆
Molecular Weight:434.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-LY-2300559 Chemical Structure

CAS No.: 889115-58-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

All mGluR Isoforms :

All Leukotriene Receptor Isoforms :

In Vitro

Glutamate Release or ReceptorsOthers

Glutamate Release or Receptors

(Rac)-LY-2300559 (compound 42) enhances glutamate-induced intracellular calcium flux in cells expressing human mGlu2 receptors, with an EC₅₀ <12.5 μM^[1].

Others

(Rac)-LY-2300559 antagonizes LTD4-induced calcium flux in cells expressing human CysLT1 receptors, with an IC50 < 12.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 889115-58-6
Molecular Weight 434.49
Formula C₂₆H₂₆O₆
SMILES

O=C(O)C1=CC=CC(=C1)C(O)C2=CC=C(C=C2)COC3=CC=C(C(=O)C)C(O)=C3CCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Aicher TD, et.al. Potentiators of glutamate receptors. WO 2006/057869 A1. Published June 1, 2006.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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(Rac)-LY-2300559

All mGluR Isoforms

All Leukotriene Receptor Isoforms