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Cat. No.: HY-N2127A

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(Rac)-Pinostrobin

Name: (Rac)-Pinostrobin
Brand: MedChemExpress
SKU: HY-N2127A
Availability: PreOrder

(Synonyms: (±)-Pinostrobin)

(Rac)-Pinostrobin ((±)-Pinostrobin) is a dual agonist of TGR5 and PPARγ. (Rac)-Pinostrobin specifically activates TGR5 without acting on other endogenously expressed GPCRs. (Rac)-Pinostrobin exhibits moderate PPARγ activation activity. (Rac)-Pinostrobin possesses metabolic regulatory activity. (Rac)-Pinostrobin can be used in research related to obesity and type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 75291-74-6
Formula: C₁₆H₁₄O₄
Molecular Weight:270.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Pinostrobin Chemical Structure

CAS No.: 75291-74-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

TGR5

PPARγ

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	37.46 μM Compound: 84	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method	[PMID: 37683361]
J774.A1	IC₅₀	19.63 μM Compound: 84	Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method	[PMID: 37683361]
RAW264.7	IC₅₀	22 μM Compound: 84	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of TNF-alpha production incubated for 18 hrs by ELISA analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of TNF-alpha production incubated for 18 hrs by ELISA analysis	[PMID: 37683361]
RAW264.7	IC₅₀	40 μM Compound: 84	Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of IL-1beta level incubated for 18 hrs by ELISA analysis Anti-inflammatory activity against mouse RAW264.7 cells assessed as inhibition of IL-1beta level incubated for 18 hrs by ELISA analysis	[PMID: 37683361]
RAW264.7	IC₅₀	23.51 μM Compound: 84	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNF-alpha level by ELISA method	[PMID: 37683361]
RAW264.7	IC₅₀	17.28 μM Compound: 84	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-stimulated IL-1beta level by ELISA method	[PMID: 37683361]

In Vitro

(Rac)-Pinostrobin ((±)-Pinostrobin) (13-100 μM; up to 40 h) activates TGR5 in TGR5-expressing HepG2 cells, producing significant, dose-dependent activation across concentrations from 13 to 100 μM^[1].
(Rac)-Pinostrobin (13-100 μM; up to 40 h) acts as a modest PPARγ activator in A9 cells, producing significant activation only at concentrations from 13 to 44 μM, with no detectable activity at higher concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Metabolic Diseases

Chemical Information

CAS No. 75291-74-6
Molecular Weight 270.28
Formula C₁₆H₁₄O₄
SMILES

O=C1C=2C(O)=CC(OC)=CC2OC(C=3C=CC=CC3)C1
Synonyms

(±)-Pinostrobin
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miyata R, et al. Takeda G Protein-Coupled Receptor 5 and Peroxisome Proliferator-Activated Receptor-Gamma Activation by Pinocembrin and Pinostrobin Isolated from Lindera sericea. Int J Mol Sci. 2026 Feb 22;27(4):2045.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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