(±)-Coriolic acid
Based on 1 Customer Validation
(±)-Coriolic acid ((±)-13-HODE) is one of the two racemic monohydroxy fatty acids produced by non-enzymatic oxidation of linoleic acid. (±)-Coriolic acid induces TNF production in macrophages and upregulates Scavenger Receptor, thereby promoting the uptake of oxidized low-density lipoprotein. (±)-Coriolic acid induces the expression of cell adhesion molecules in endothelial cells. (±)-Coriolic acid can be used in research on psoriasis, atherosclerosis, and triple-negative breast cancer.
For research use only. We do not sell to patients.
- Purity : 98.02%
- CAS No.: 18104-45-5
- Formula: C18H32O3
- Molecular Weight:296.44
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:231-FABP7 and 231-RFP TNBC cells
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Concentration:25 nM co-treated with 12.5 µM Linoleic acid
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Incubation Time:72 h
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Result:Attenuated the cell death induced by Linoleic acid.
In Vivo
(±)-Coriolic acid (8 mg; p.o.; 5 days per week; 11 weeks) decreases plasma triglyceride concentrations in LDL receptor knockout mouse models fed a non-purified diet[4].
(±)-Coriolic acid (8 mg; p.o.; 5 days per week; 13 weeks) increases aortic atherosclerotic lesion area in LDL receptor knockout mouse models fed a medium-fat and low-fat diet[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LDL receptor knockout male mice (4-6 wk of age; high fat diet TD88137)[4]
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Dosage:8 mg
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Administration:p.o.; 5 d/wk; 11 wk
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Result:Increased aortic lesion area by 100%.
Increased plasma LDL cholesterol (10.90 mM vs. 8.65 mM).
Increased the TC:HDL cholesterol ratio (4.89 vs. 4.15).
Elevated plasma autoantibody levels to oxidatively modified proteins (1.19 OD vs. 0.88 OD).
Did not affect plasma ApoA1 levels.
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Animal Model:LDL receptor knockout male mice (4-6 wk of age; medium fat diet TD01073)[4]
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Dosage:8 mg
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Administration:p.o.; 5 d/wk; 13 wk
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Result:Increased aortic lesion area compared with untreated controls.
Did not affect plasma total or LDL cholesterol levels.
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Animal Model:LDL receptor knockout male mice (4-6 wk of age; low fat diet TD01074)[4]
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Dosage:8 mg
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Administration:p.o.; 5 d/wk; 13 wk
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Result:Increased aortic lesion area compared with untreated controls.
Reduced plasma HDL cholesterol (2.43 mM vs. 2.72 mM).
Increased the TC:HDL cholesterol ratio.
Did not affect plasma total or LDL cholesterol levels.
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Animal Model:LDL receptor knockout male mice (4-6 wk of age; nonpurified diet LabDiet 5001)[4]
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Dosage:8 mg
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Administration:p.o.; 5 d/wk; 11 wk
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Result:Did not cause lesion formation.
Decreased plasma triglyceride concentration (1.55 mM vs. 2.02 mM).
Did not affect total, HDL, or LDL cholesterol concentrations.
Plasma autoantibody levels to oxidatively modified proteins did not differ between treated and untreated mice.
Chemical Information
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CAS No. 18104-45-5
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Appearance Liquid
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Molecular Weight 296.44
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Formula C18H32O3
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Color Colorless to light yellow
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SMILES
CCCCCC(O)/C=C/C=C\CCCCCCCC(O)=O
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Synonyms
(±)-13-HODE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[4]. Khan-Merchant N, et al. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. The Journal of nutrition. 2002 Nov;132(11):3256-62. [Content Brief]
[5]. Nishizuka Y, et al. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (New York, N.Y.). 1992 Oct 23;258(5082):607-14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)-Coriolic acid Related Classifications
HY-113884A Related Classifications
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