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Cat. No.: HY-105249B

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RDEA 806 potassium

RDEA 806 potassium is an orally effective non-nucleoside reverse transcriptase (NNRT) inhibitor that exhibits potent in vitro inhibitory activity against wild-type HIV-1 (EC₅₀ = 1.7 ng/mL) and NNRTI-resistant HIV-1. RDEA 806 potassium rapidly reduces HIV-1 RNA viral load in vivo. RDEA 806 potassium has a favorable biosafety profile. RDEA 806 potassium can be used for research related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 878670-63-4
Formula: C₂₄H₁₇BrClKN₄O₃S
Molecular Weight:595.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RDEA 806 potassium Chemical Structure

CAS No.: 878670-63-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All HIV Isoforms :

In Vitro

Viral Infection

RDEA 806 potassium exhibits potent in vitro activity against wild-type HIV-1 with an EC₅₀ of 1.7 ng/mL and retains activity against common NNRTI-resistant mutants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 878670-63-4
Molecular Weight 595.94
Formula C₂₄H₁₇BrClKN₄O₃S
SMILES

O=C(C1=CC=C(C(Cl)=C1)NC(CSC2=NN=C(N2C3=C4C=CC=CC4=C(C5CC5)C=C3)Br)=O)O[K]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moyle G, et al. Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects. Antimicrobial agents and chemotherapy. 2010 Aug;54(8):3170-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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