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Cat. No.: HY-N21746

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Rhodomollein XI

Rhodomollein XI is a naturally occurring grayanane diterpenoid with anti-inflammatory and analgesic activities. Rhodomollein XI inhibits LPS-induced NO production in RAW264.7 mouse macrophages. Rhodomollein XI exhibits analgesic effects in the mouse acetic acid-induced writhing test. Rhodomollein XI can be used for pain- and inflammation-related research.

For research use only. We do not sell to patients.

CAS No.: 798558-82-4
Formula: C₂₂H₃₆O₈
Molecular Weight:428.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rhodomollein XI Chemical Structure

CAS No.: 798558-82-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC50	9.3 μM	Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 mouse macrophages.	29272126

In Vitro

Oxidative Stress

Rhodomollein XI (compound 25) exhibits significant inhibitory activity against LPS-induced NO production in RAW264.7 mouse macrophages, with an IC₅₀ of 9.3 μM, and shows no cytotoxicity at 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rhodomollein XI (compound 4) (1 mg/kg; single intraperitoneal administration) produces a significant analgesic effect in the acetic acid-induced writhing model in mice, with a writhing inhibition rate of 91.7%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 798558-82-4
Molecular Weight 428.52
Formula C₂₂H₃₆O₈
SMILES

O[C@H]1[C@@]23[C@](CC[C@@]1([H])[C@](O)(C3)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C2)OC(C)=O)(C(C)([C@H]([C@@H]4O)O)C)O)C
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou J, et al. Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle. Journal of natural products. 2018 Jan 26;81(1):151-161. [Content Brief]

[2]. Wang Y, et al. Three new antinociceptive diterpenoids from the flowers of Rhododendron molle. Journal of Asian Natural Products Research, 2025, 27(11):1619-1629.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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