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Cat. No.: HY-210247

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RIPK2-IN-9

RIPK2-IN-9 is a RIPK2 inhibitor with an IC₅₀ < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 3066447-73-9
Formula: C₂₆H₃₀F₂N₆O
Molecular Weight:480.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RIPK2-IN-9 Chemical Structure

CAS No.: 3066447-73-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All RIP kinase Isoforms :

All NOD-like Receptor (NLR) Isoforms :

All TNF Receptor Isoforms :

All NF-κB Isoforms :

In Vitro

RIPK2-IN-9 (Compound 181) inhibits NOD2-mediated NF-κB reporter signaling in HEK-Blue™-hNOD2 cells with an hNOD2 IC₅₀ of 1 nM^[1].
RIPK2-IN-9 exhibits low inhibitory activity against the hERG potassium channel in CHO-hERG cells, with an hERG IC₅₀ of 10 μM, indicating a favorable cardiac safety profile^[1].
RIPK2-IN-9 inhibits the protein-protein interaction between RIPK2 and XIAP in HEK293T cells, with an IC₅₀ of 8.1 nM in the NanoBRET assay^[1].
RIPK2-IN-9 inhibits NOD2 ligand L18-MDP (HY-148690)-induced TNF-α secretion in human whole blood from healthy donors, with an MSD immunoassay IC₅₀ of 0.4 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 3066447-73-9
Molecular Weight 480.55
Formula C₂₆H₃₀F₂N₆O
SMILES

CC1=CC(F)=C(C(NC2CC2)=O)C=C1N3C=C(C4=CN=CC(N[C@@H]5[C@@H](CN(CC5)CC)F)=C4)C=N3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vanhuis C, et al. Inhibitors of RIPK2 and uses thereof. WO 2024/259328 A1. 2024-12-19.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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RIPK2-IN-9

All RIP kinase Isoforms

All NOD-like Receptor (NLR) Isoforms

All TNF Receptor Isoforms

All NF-κB Isoforms