country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184894

Copy Link Print Information

RK-1205-I

RK-1205-I is a protein phosphatase 2A (PP2A) inhibitor and fungal growth inhibitor. RK-1205-I inhibits PP2A activity in fungal cells, leading to the accumulation of Ser/Thr phosphorylated proteins. RK-1205-I acts as a morphoregulator and induces unique morphological changes in filamentous fungi. RK-1205-I inhibits the growth of various fungi, including Aspergillus oryzae, Aspergillus fumigatus and Candida auris. RK-1205-I can be used for the research of fungal infections.

For research use only. We do not sell to patients.

Formula: C₃₁H₄₉O₁₀P
Molecular Weight:612.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RK-1205-I Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

PP2A

In Vitro

Fungal InfectionAnti-cancerOthers

Fungal Infection

RK-1205-I (Compound 1) potently inhibits the growth of various fungi (e.g., A. fumigatus, Candida spp., P. oryzae), with IC₅₀ values ranging from 0.020 to 0.55 µM^[1].
RK-1205-I (0.062-0.186 µM; 48 h) induces unique morphological changes in Aspergillus oryzae^[1].

Anti-cancer

RK-1205-I potently inhibits the growth of HL-60 cells, with an IC₅₀ of 0.2 µM^[1].

Others

RK-1205-I (0.01-10 µM; 2 h) inhibits PP2A activity and increases the accumulation of serine/threonine phosphorylated proteins in Candida albicans and HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Candida albicans SC5314, HL-60 RCB0041 cells
Concentration:

0.01, 0.1, 1, 10 µM
Incubation Time:

2 h (28 °C for C. albicans; 37 °C for HL-60 cells)
Result:

Induced accumulation of serine/threonine-phosphorylated proteins in both C. albicans and HL-60 cells across all tested concentrations.

In Vivo

Fungal Infection

RK-1205-I (0.01-200 µg/larva; intravenous injection; single administration) exerts significant antifungal effects on C. albicans-infected silkworms, with a T/C value of 1.4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Bombyx mori Kinshu × Showa (fifth-instar larvae, 2.0 g)^[1]
Dosage:

0.01, 200 µg/larva (toxicity assessment)
Administration:

i.v.; single dose
Result:

Improved silkworm survival rate significantly, with a T/C value of 1.4.
Showed no toxicity to silkworms for at least 96 h at a dose of 200 µg/larva.

Related Protocols :

Filamentous Fungal Mold Culture and Sporulation

Chemical Information

Molecular Weight 612.69
Formula C₃₁H₄₉O₁₀P
SMILES

O=C1C=CC[C@H](/C=C/[C@@](C)(O)[C@H](OP(O)(O)=O)C[C@@H](O)/C=C\C=C/C=C/COC(CCCCCCCCC(C)C)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Futamura Y, et al. Artificial intelligence-based phenotypic screening using Aspergillus oryzae identified a novel antifungal RK-1205-I. J Antibiot (Tokyo). 2026 Jun 19. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote