RN193
RN193 is a type II kinase inhibitor with a human PAK1 IC50 of 4.28 μM. RN193 functionally inhibits kinase activity of PAK1, PAK2, and PAK3, and engages with their kinase domains in live cells. RN193 induces thermal shifts in CLK1, GSK3B, ULK1, MELK, MAPK13, BRAF, and STK10, indicating binding and stabilization of these proteins. RN193 induces formation of PAK3:PAK2 heterodimers and displaces PAK2 homodimers in live cells. RN193 acts as a tool compound for studying group I PAK conformational states.
For research use only. We do not sell to patients.
- CAS No.: 3091508-49-2
- Formula: C30H32N6O3
- Molecular Weight:524.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PAK1M248-H545 4.25 μM (IC50) |
PAK2 |
PAK3 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3091508-49-2
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Molecular Weight 524.61
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Formula C30H32N6O3
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SMILES
O=C(C1(CC1)C(NC2=CC(C(C)C)=CC=C2)=O)NC3=CC(C4=CNC5=NC=NC(N6CCOCC6)=C54)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RN193 Related Classifications
HY-184447 Related Classifications
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