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Cat. No.: HY-134146

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ROCK2-IN-20

ROCK2-IN-20 is a selective ROCK2 inhibitor with an IC₅₀ value of 12 nM. ROCK2-IN-20 can be used for research on multiple sclerosis, pulmonary arterial hypertension, and glaucoma.

For research use only. We do not sell to patients.

CAS No.: 1219722-56-1
Formula: C₁₉H₂₀N₄O₂
Molecular Weight:336.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ROCK2-IN-20 Chemical Structure

CAS No.: 1219722-56-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

ROCK2-IN-20 is a selective ROCK2 inhibitor with an IC₅₀ value of 12 nM. ROCK2-IN-20 can be used for research on multiple sclerosis, pulmonary arterial hypertension, and glaucoma^[1].

IC₅₀ & Target

^[1]

ROCK2

12 nM (IC₅₀)

PKA

610 nM (IC₅₀)

All ROCK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A7R5	IC₅₀	59 nM Compound: 12o	Inhibition of ROCK-mediated myosin light chain bisphosphorylation in rat A7R5 cells after 1 hr by fluorescence assay in presence of L-alpha-lysophosphatidic acid Inhibition of ROCK-mediated myosin light chain bisphosphorylation in rat A7R5 cells after 1 hr by fluorescence assay in presence of L-alpha-lysophosphatidic acid	[PMID: 23570561]

In Vitro

ROCK2-IN-20 (Compound 56) inhibits ROCK2 in the STK2 biochemical assay with an IC₅₀ of 12 nM, and shows an IC₅₀ of 610 nM against PKA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 1219722-56-1
Molecular Weight 336.40
Formula C₁₉H₂₀N₄O₂
SMILES

O=C(NC=1C=CC(=CC1)C=2C=NNC2)N(CC=3C=CC=CC3)CCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mei D, et al. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations. Bioorganic & medicinal chemistry. 2015 May 15;23(10):2505-17. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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