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Cat. No.: HY-156592

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Fimosudil

Name: Fimosudil
Brand: MedChemExpress
SKU: HY-156592
Availability: PreOrder

(Synonyms: ROCK2-IN-6)

Fimosudil (ROCK2-IN-6) is a selective ROCK2 inhibitor for research on ROCK-mediated diseases, autoimmune diseases, and inflammation.

For research use only. We do not sell to patients.

CAS No.: 2260506-59-8
Formula: C₂₆H₂₁F₂N₇O
Molecular Weight:485.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Fimosudil Chemical Structure

CAS No.: 2260506-59-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Fimosudil (ROCK2-IN-6) is a selective ROCK2 inhibitor for research on ROCK-mediated diseases, autoimmune diseases, and inflammation^[1].

IC₅₀ & Target

^[1]

ROCK2

All ROCK Isoforms :

In Vitro

ROCK (Rho-associated coiled-coil-containing protein kinase) is a serine/threonine protein kinase that serves as a key downstream effector of RhoA. By regulating actin-myosin contractility, it participates in processes such as cell motility, smooth muscle contraction, and proliferation, and its abnormal activation is closely associated with fibrotic, autoimmune, and inflammatory diseases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 2260506-59-8
Molecular Weight 485.49
Formula C₂₆H₂₁F₂N₇O
SMILES

O=C(N1CC(F)(C1)F)C2=CC3=C(N2C)C=C(C4=NC(NC5=CC=C(C6=CNN=C6)C=C5)=CC=N4)C=C3
Synonyms

ROCK2-IN-6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang HJ, et al. Solid form of rho-associated protein kinase inhibitor or solvate thereof, preparation method and use thereof

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Fimosudil

All ROCK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Fimosudil Related Classifications

HY-156592 Related Classifications

Bioz

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